Predict AAT
Friedrich Kueppers, M.D.
In a recent publication (1) we described an algorithm that allows adjustment of Alpha–1 Antitrypsin (AAT) levels to the levels of C–reactive protein (CRP) and AAT genotype. Both proteins belong to the group of acute phase reactants, whose blood levels rise in response to an acute phase stimulant (i.e. inflammation, infection, injury). CRP is commonly measured as an indicator of an acute phase. The blood levels of AAT and CRP are closely correlated. An additional factor that influences the level of AAT is the AAT (PI*) genotype. Several genotypes are associated with levels that also differ in their acute phase response.
The graphic shows the levels of AAT of common genotypes (MM, MZ, MS) at baseline (solid line) and during an acute phase (dotted line) when CRP is elevated ( >5 mg/L). The online calculator given here is based on the algorithm for the adjustment of AAT, according to CRP levels, and AAT genotype. To use it, enter the values of AAT, CRP and AAT genotype in the indicated fields and press “calculate.” The result will show the predicted level of AAT at baseline as it would be in the absence of an acute phase.
Reference
Sanders, CL, Ponte, A, Kueppers, F The Effects of Inflammation on Alpha–1 Antitrypsin Levels in a National Screening Cohort. COPD: Journal of Chronic Obstructive Pulmonary Disease. 2018; 15 (1) 10-16.
AAT LEVEL PREDICTOR
Calculate Predicted AAT from Observed AAT and CRP.
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